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Sunday sees the initial Wear-Tyne derby since 2024, but who will emerge victorious – Sunderland or Newcastle?
"For most of last season, no one would have predicted Sunderland getting promoted and being competitive with Eddie Howe's Newcastle, let alone being above them in the table," commented pundit Chris Sutton.
"Things are very different now, and the way they play convinces me they've got a genuine opportunity."
Sutton is making scoreline guesses for all 380 Premier League games this season, in competition with artificial intelligence, fans and a range of guests.
For week 16, he is challenged by England Gaming star Daniel 'Stingray' Ray.
Ray is competing for honours for the England's esports team – the Football Association's official esports team – at the football simulation digital Euros finals tournament, which takes place at Twickenham Stadium on Saturday.
Viewers can catch Uefa's video platform, Instagram Live and short-form video channels, as well as EA Sports FC Twitch and YouTube and the national team's Twitch.
Do you agree with their scores? Feel free to submit your own guesses below.
The fan-favourite scoreline selected for each game is used in the tables at the end of this page.
Getting the win/draw/loss right (picking a win, draw or defeat) is worth 10 points. A perfect prediction earns forty points.
Ray, who competes for his club side and the Premier League champions as well as England, is entering the fray at the eEuros finals after successfully navigating the qualifying.
Eight players will play for their countries at the finals in a single-elimination, playing for a $100,000 prize pool and a highly sought-after spot in the FC Pro World Championship Play-Ins, with Denmark's Anders Vejrgang defending the title he won last year.
"My mindset is really good for it," Ray said. "I have a really good coach with me and preparation has been going well.
"Representing your country is always an honour to play for your country. Naturally when you are younger, you dream about doing it as an real-life footballer, but when you pursue a career in this field and there is an chance to represent England, putting the shirt on is something unique.
"I overcame Vejrgang 9-4 in qualifying to get here. I've played against him recently just in practice, and in other tournaments before - but I'd never beaten him in a tournament before.
"In my opinion he is the top competitor in the world so getting a win over him in a tournament like this just delivers a huge surge of confidence."
Premier League Weekend Preview
Saturday, 13 December
Chelsea vs Everton
Stamford Bridge, 15:00 GMT
The London club were impressive against the Gunners at the end of November, when they secured a point after going down to 10 men, and it seemed they've turned a corner, they could possibly be challengers for the crown.
In the matches following, however, they were overpowered by Leeds, looked flat against Bournemouth and this week got defeated by Atalanta in the Champions League.
So manager Enzo Maresca desperately requires a win here to get back on track, but it will be a challenge because the Toffees are such a dangerous team.
Their key midfielders are playing at the top of their game and they have got a bit of momentum at the moment.
Based on recent performances you would probably back the visitors, while the most sensible prediction would likely be a draw, but I am not going to be sensible.
Chelsea haven't given me any good cause to back them recently, but I just have a gut instinct they will emerge victorious because they are at home and they are overdue a victory.
Sutton's prediction: 2-1
Stingray's prediction: With this being at the Bridge, I am going to back Chelsea. I think they will start off really well and go 2-0 up, then Everton will nick one back but then Chelsea score late. 3-1
AI's prediction: 2-0
Liverpool vs Brighton
Anfield, 15:00 GMT
I'm attending this game and it will be fascinating to see what we get from Liverpool.
I am really pleased for Reds boss Arne Slot to get such a important victory at Inter Milan on Tuesday after all the controversy with Mohamed Salah this week.
Slot ought not to put up with that nonsense. I know Salah has been a great for the club but fundamentally Slot just wants to win games and there is nothing personal in his team selection.
They changed their formation against Inter and went with a midfield diamond formation and two up top.
Everyone is going to be talking about whether Salah is included for this game, but the only way he is going to be reintegrated is if he makes amends.
Slot's focus will be on winning this game, but it is a tough one.
You could argue it is the same for most teams but I find Brighton so unpredictable. I always feel they have got a goal in them, but they are quite open too.
The Merseysiders need to get back to stringing wins together, but I am not sure how much their exertions at the San Siro will have drained them.
I've selected a couple of Brighton players in my FPL team, so they will almost certainly blank - but I do fancy get something at Anfield.
Sutton's prediction: 2-2
Stingray's prediction: This is a game which is going to give Liverpool a bit more of their confidence back. Obviously they had a good win in midweek and they can build more momentum here. 2-1
AI's prediction: 3-1
Sunday, 14 December
Sunderland vs Newcastle
Stadium of Light, 14:00 GMT
Sunderland have had the benefit of a free week while Newcastle had to battle intensely against Bayer Leverkusen on Wednesday, only to be pegged back late on.
Aside from their brilliant performance against Everton a couple of weeks ago, Newcastle's away form hasn't been great, especially straight after they've played in the Champions League.
It is anticipated that that trend to continue on Sunday, and their fatigue is likely to be a key element in how this game goes because of Sunderland's intensity.
We saw how relentless Regis le Bris's side are. They overpowered the Gunners, and it was a joy to watch.
Everyone talks about how Granit Xhaka has been brilliant for the Black Cats, and he has been excellent, but Noah Sadiki, who plays next to him, has also been one of the top transfers and deserves some attention too.
This promises to be this being the best game|most exciting fixture